Translation and the ribosome

The Dworkin lab studies regulation of translation during nutrient limitation in bacteria, with a particular focus on the phenomenon of ribosome dimerization.

The Frank lab is interested in time-resolved cryo-electron microscopy of the translational machinery in bacteria and eukaryotes

The Gonzalez lab focuses on the thermodynamics, kinetics and structures of biomolecular assemblies and molecular motors, with specific emphasis on the ribosome and protein synthesis.

The Hunt lab employs diverse biophysical and molecular biological methods to elucidate the mechanisms of complex biomolecular processes including the influence of synonymous codon variations and ABCF proteins on mRNA translation and the structural mechanics of transmembrane transporters.

The Kieft lab is interested in how the complex and dynamic 3-D structures of RNA, and their interactions with other molecules, lead to diverse biological functions.

The Liao lab is interested in mRNA localization and translation in the brain.

The Sanbonmatsu lab integrates molecular simulation, cryo-EM and biochemistry to understand the mechanism of ribosomes, riboswitches and non-coding RNAs.

In the Steckelberg lab, we combine RNA biology, structural biology and virology to study how viruses manipulate cellular gene expression.