Structure, dynamics, biophysics

The Al-Hashimi group develops quantitative and predictive models of RNA cellular activity through the determination of RNA conformational ensembles showing how their 3D structures vary with time.

The Dworkin lab studies regulation of translation during nutrient limitation in bacteria, with a particular focus on the phenomenon of ribosome dimerization.

The Gonzalez lab focuses on the thermodynamics, kinetics and structures of biomolecular assemblies and molecular motors, with specific emphasis on the ribosome and protein synthesis.

The Hunt lab employs diverse biophysical and molecular biological methods to elucidate the mechanisms of complex biomolecular processes including the influence of synonymous codon variations and ABCF proteins on mRNA translation and the structural mechanics of transmembrane transporters.

The Kieft lab is interested in how the complex and dynamic 3-D structures of RNA, and their interactions with other molecules, lead to diverse biological functions.

The Sanbonmatsu lab integrates molecular simulation, cryo-EM and biochemistry to understand the mechanism of ribosomes, riboswitches and non-coding RNAs.

In the Steckelberg lab, we combine RNA biology, structural biology and virology to study how viruses manipulate cellular gene expression.

The Tong lab uses structural biology techniques to study the molecular mechanism of RNA 3'-end processing, 5' decapping, degradation and related events