RNA-targeted therapeutics, disease

The Al-Hashimi group develops quantitative and predictive models of RNA cellular activity through the determination of RNA conformational ensembles showing how their 3D structures vary with time.

The Basu lab is interested in studying RNA surveillance, noncoding RNA processing and DNA alteration events in lymphocytes

The Berchowitz lab examines how various types of condensates give rise to emergent properties beyond those of the constituent proteins and how healthy cells regulate these structures.

The Chung lab is interested in understanding how RNA sensing shapes human immune responses in infection, autoimmunity, and neural disease

The Gaublomme lab develops optical pooled CRISPR screens with multi-omic in situ readout to understand cellular function and intercellular communication.

The Goff lab studies retrovirology; HIV-1; murine leukemia viruses; endogenous retroviruses; host restriction factors.

The Manley lab is interested in studying mechanisms of mRNA processing: Regulation and links to human disease.

The Small-Saunders lab studies epigenetic and epitranscriptomic mechanisms of drug resistance and stress responses in Plasmodium falciparum parasites, including tRNA modification reprogramming and long noncoding RNAs.

The Wu lab is interested in decoding and targeting RNA in health and disease

The Zaccara lab is dedicated to investigating the fundamental mechanisms that regulate mRNA fate in both normal and disease states, with a specific focus on understanding the role of RNA modifications